Target your deepest wrinkles and dark spots with the Vital Perfection Wrinkle Spot Treatment. Shiseido’s powerful 2-in-1 treatment visibly reduces wrinkles, smile lines, and dark spots at their root, using breakthrough ReNeura Technology++ and concentrated retinol. Enhance its effects with the full Vital Perfection routine. Retinol, vitamin A, improves the look of wrinkles by maintaining healthy skin turnover for youthfulness and radiance. 48 hours of moisture* helps keep skin plump and protected. Our innovation. Our research. Your results. Visibly reduced wrinkles, smile lines, and dark spots within 4 weeks.**How To Apply: Use morning and night as the last skincare step. During the day, follow with sunscreen to ensure the effectiveness of the retinol. Method 1 – Wrinkle and Spot Treatment: Take a pearl-sized drop and place cream on 3 areas of the face: 1) wrinkles under the eyes and in the outer corners, 2) smile lines (nasolabial folds) and wrinkles around the mouth, and 3) dark spots. An additional pearl-sized drop can be used for the neck. Step 1: Eye Area: With the middle and ring fingers of both hands, gently smooth cream along the bottom of the eyes, from the inner corners to the outer corners. With one hand, gently stretch crow’s feet flat. With the middle finger of the other hand, apply the cream in up-and-down motions. Step 2: Mouth Area: With the middle and ring fingers of both hands, gently stretch smile lines and skin around the mouth to each side and blend cream into skin. Step 3: Dark Spots: With the middle fingers of both hands, gently smooth cream onto areas of uneven skin and dark spots in circular motions. Step 4: Neck Area: Lift chin to stretch neck wrinkles out. Smooth cream over the area. With your right hand, gently smooth the cream over the left side of the neck, from the bottom upward. Repeat on the right side using your left hand. Method 2 – Wrinkle Lifting Smile-Line Exercise: Smile wide so that the corners of your mouth turns upward and your teeth are showing. While still smiling, slowly lift your head up and hold for 10 seconds while massaging. Dermatologist-tested.* Instrumental test on 10 volunteers.** Clinical test on 37 volunteers.